Ekstrak Patikan Kebo (Euphorbia hirta L.) Menurunkan Kadar Eosinofil Darah Pada Tikus Wistar Model Alergi

  • Danus Hermawan Universitas Sebelas Maret
  • Siti Ma'rufah Universitas Sebelas Maret
  • Diding Heri Prasetyo RSUD Dr. Muwardi Solo
  • Jarot Subandono Universitas Sebelas Maret
Keywords: alergi, eosinofil, ovalbumin, patikan kebo

Abstract

Paparan alergen berupa ovalbumin pada tubuh secara berulang memicu terjadinya reaksi alergi. Alergi diperantarai oleh IgE yang terikat pada permukaan sel mast atau basophil dan menyebabkan dilepaskannya mediator kimia seperti bradikinin, histamin, prostaglandin yang memicu terjadinya inflamasi sistemik yang ditandai dengan peningkatan eosinofil darah. Peningkatan eosinofil darah dapat ditekan oleh asam kafeat, kuersetin, dan flavonoid. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak patikan kebo terhadap kadar eosinofil darah pada tikus Wistar model alergi. Subyek penelitian berupa 25 ekor tikus Wistar jantan dengan berat badan ± 200 gram dan berumur 6 minggu, dibagi dalam 5 kelompokyaitu: Kontrol (K), Alergi (A), ekstrak patikan kebo 10 mg/tikus/hari(P1), ekstrak patikan kebo 15 mg/tikus/hari (P2), ekstrak patikan kebo 20 mg/tikus/hari (P3). Kadar eosinofil darah pretes diukur hari ke-14 dan postes diukur setelah 28 hari perlakuan. Kadar eosinofil darah dianalisis dengan SPSS versi 23.0 menggunakan uji t berpasangan. Tingkat kemaknaan digunakan p<0,05. Kadar eosinofil darah tikus P1, P2, dan P3 lebih rendah secara bermakna dibanding tikus Alergi (p<0.05). Patikan kebo mampu menurunkan kadar eosinofil darah pada tikus Wistar model alergi.

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Published
2019-02-28
How to Cite
Hermawan, D., Ma’rufah, S., Prasetyo, D., & Subandono, J. (2019). Ekstrak Patikan Kebo (Euphorbia hirta L.) Menurunkan Kadar Eosinofil Darah Pada Tikus Wistar Model Alergi. Majalah Farmasi Nasional, 16(1), 1-5. Retrieved from https://uit.e-journal.id/MFN/article/view/110

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